For this kind of issues you need to engage VMware support on this, following any part of this article could lead to more complex situation if not ran by an expert.
Symptoms A datastore has become inaccessible. A VMFS partition table is missing. Purpose The partition table is required only during a rescan. This means that the datastore may become inaccessible on a host during a rescan if the VMFS partition was deleted after the last rescan. The partition table is physically located on the LUN, so all vSphere hosts that have access to this LUN can see the change has taken place. However, only the hosts that do a rescan will be affected. This article provides information on: Determining whether this is the same problem Resolving the problem Cause This issue occurs because the VMFS partition can be deleted by deleting the datastore from the vSphere Client. This is prevented by the software, if the datastore is in use. It can also happen if a physical server has access to the LUN on the SAN and does an install, for example. Resolution To resolve this issue: Run the partedUtil command on the host with the issues and verify if your output